Besides the posttranslational modification of NF-κB itself, novel activators of NF-κB, such as the transcription factor Y-box protein 1 (YBX1) is highly expressed in many cancers and is an excellent marker for cancer.YBX1 was recently investigated by our lab, and e found that overexpression of YBX1 is connected to activation ofNF-κB. Here, YBX1 is linked to cancer.