These factors may functionally activate EMT-inducing transcription factors, such as Snail (SNAI1), Slug (SNAI2), zinc finger E-box binding homeobox 1 (ZEB1), Twist family BHLH Transcription Factor 1 (Twist), Goosecoid (GSC), and forkhead box protein C2 (FOXC2) in cancer cells []. This evidence concerns the gene FOXC2 and cancer.