Patients with significantly impaired FS (the moderate or severe group) tended to be older, female, have CGN as a cause of ESKD less often, have more co-morbidities (e.g., vascular diseases, malignancy, liver disease, and dementia), have a higher prevalence of temporary catheter as a type of vascular access, and have lower serum albumin and higher CRP levels, all of which can be judged as clinically significant. This evidence concerns the gene ALB and liver disorder.