PPARD and breast carcinoma: For example, PPARδ expression is inversely correlated with survival in gastrointestinal cancers.38 Consistent with our findings (Figure 1), PPARδ has been implicated as an important transcriptional node in breast cancer, and shorter survival of breast cancer patients is associated with increased expression of PPARδ by their tumor cells (Figure 2).10 Synthetic PPARδ ligands also promote breast cancer progression and metastasis in transgenic mice.37