Aberrant activation of NIK has been shown to have oncogenic roles in several cancers, including melanoma, ovarian cancer and multiple myeloma,39, 40, 41 primarily through regulation of proliferation and cell survival.33, 41, 42 However, the role of NIK in CNS tumor pathogenesis, and particularly in tumor cell invasion, has not been clearly established. The gene discussed is MAP3K14; the disease is plasma cell myeloma.