NFKB1 and neoplasm: Several studies have established a role for canonical NF-κB-dependent (p65-mediated) regulation of MT1-MMP expression.24, 25 In addition, Fritz and Radziwill26 demonstrated that noncanonical NF-κB signaling (RelB-p52-mediated) regulates MT1-MMP expression and tumor cell invasion induced by the scaffold protein CNK1.