Consistent with previous findings in Glis3zf/zf mice [1], the expression of Ins1 and Ins2 was also greatly decreased in Glis3KO2 pancreas and loss of Glis3 expression induced development of pancreatic cysts suggesting a regulatory role in pancreatic duct morphogenesis (Fig 6B). The gene discussed is GLIS3; the disease is Pancreatic cysts.