Hansson [8] describes, for example, the development of an inflammatory cascade in atherosclerosis, involving, but not limited to, inflammatory cytokines (e.g. tumor necrosis factor alpha (TNF-α), interleukin-1 (Il-1)), interleukin-6 (Il-6), and acute-phase reactants (e.g. C-reactive protein (CRP)). The gene discussed is TNF; the disease is atherosclerosis.