The expression of CD144 on annexin-V- was low, demonstrating that most Ec-MPs in the urine display the annexin-V binding phospholipid phosphatidylserine [% annexin-V- CD144+: CTRL: 4.6 ±1.3; PAH: 2.63 ± 0.64, p<0.19]. The gene discussed is ANXA5; the disease is pulmonary arterial hypertension.