It has recently been reported that the mutation c.1082G>A (p.Arg361Gln), identified in 2.4% of the 125 Finnish high-risk breast cancer families (P = 0.002 –familial cases versus controls), which impaired the localization of the protein in cultured cells, caused hypersensitivity to IR and reduced BRCA1 localization at sites of DNA damage [27]. This evidence concerns the gene BRCA1 and breast cancer.