SUB1 and melanoma: Moreover, it is currently the most clinically advanced inhibitor.66 Studies in various cancer cell lines (prostate, lung, colon, melanoma, hematopoietic malignancies and urothelial tumors) demonstrated that volasertib inhibits cell division leading to cell death.67, 68, 69, 70 Additionally, we also observed that SUB1 also regulates BUB1B.