PTGS2 and Familial prostate cancer: Our previous studies showed that genomic loci encoding miR-101 were deleted in aggressive prostate cancer leading to reduced miR-101 expression, resulting in overexpression of histone methyltransferase enhancer of zeste homolog 2 (EZH2).11 Apart from regulating EZH2, it has been shown that miR-101 can target other critical genes such as COX2 (cyclooxygenase-2), POMP (proteasome maturation protein), CERS6, STMN1, MCL-1 and ROCK2, among others.11, 12, 13, 14, 15, 16