We further demonstrated that the frequency of IL10+ B cells was also significantly lower in DM patients than in healthy controls (1.139 ± 0.156% vs 2.372 ± 0.205%, p < 0.001), which is consistent with previous reports describing a similar trend in the CD19+ CD24highCD38high Bregs and IL-10+ B cells of patients with other diseases25, 26. Here, IL10 is linked to dermatomyositis.