CXCL8 and neoplasm: When the up-regulation of CXCL15 (B16F0 cells) and IL-8 (HepG2 cells) was inhibited, 14,15-EET failed to promote the neutrophilic infiltration and the development of micrometastases (Figure 3E and Supplementary Figure S4D), suggesting that 14,15-EET indeed promoted neutrophilic infiltration in metastatic lesions by up-regulating neutrophil chemoattractant expression in tumor cells.