Considering the function of miR-10a depend on its down-stream target and EphA8 played an important role during apoptosis [29], we hypothesize that RP11-838N2.4 reverses the inhibitory effect of miR-10a on TMZ sensitivity of GBM because of attenuations miR-10a inhibition of EphA8. Here, EPHA8 is linked to glioblastoma.