Examples of the impact of sodium ibuprofen on melanoma invasion are shown in Fig 5 which shows results from four such experiments where it was noticeable that in these models, which were all deliberately wounded and then a fibrin clot and 300U/ml TNF-α added, the integrity of the resulting dermis was very poor and the wound repair was variable in the absence of ibuprofen (see Fig 5A, 5C, 5E and 5G). Here, TNF is linked to melanoma.