Cinnamaldehyde improves metabolic disorders in rodents, decreases ROS production and IL-1β secretion in lipopolysaccharide-stimulated murine J774A.1 macrophages, suppresses plasma TLR4 expression in myocardium of viral myocarditis mice, and alleviates ischemic myocardial injury of rats, exhibiting its anti-oxidative and anti-inflammatory property32, 34, 35, 36. Here, TLR4 is linked to metabolic disease.