Transport of ER-derived cholesterol to MVBs ensures that EGF-stimulated ILV formation proceeds to completion, even when LDL-cholesterol in the endocytic pathway is low, as found for example in cells from familial hypercholesterolemia patients carrying mutations that prevent LDL uptake (Soutar and Naoumova, 2007). The gene discussed is EGF; the disease is familial hypercholesterolemia.