MAP3K12 and glaucoma: The high stakes outcomes of regeneration or death, combined with additional findings that DLK mediates cell death in models for nerve growth factor withdrawal (Huntwork-Rodriguez et al., 2013; Ghosh et al., 2011), glaucoma (Welsbie et al., 2013), MPTP toxicity (Mathiasen et al., 2004) and excitotoxicity (Pozniak et al., 2013), have inspired much interest in understanding the unknown pathways that lead to the activation of DLK/Wnd in injured axons.