Because EGFR-mutated NSCLC shows high DPD expression while EGFR wild-type shows low DPD expression, which correlate with EGFR-TKI and 5-FU sensitivity, we considered that there is a biological rationale for studying the interplay between EGFR mutation status and DPD expression for drug selection and personalized chemotherapy. Here, EGFR is linked to non-small cell lung carcinoma.