MAP2K7 and adrenal cortex carcinoma: BRAF mutations are rarely seen in ACC; notably, comprehensive genomic profiling identified rearrangements in 23 % of ACC involving either BRAF or RAS. The most prevalent fusion SND1-BRAF activated the MAPK pathway and made the cells sensitive for MEK inhibitor trametinib, so this pathway might be useful as therapeutic target for a subgroup of patients with ACC [141].