However, the intra-peritoneal reconstitution of the SG−/− mice with serglycin-competent bone marrow derived MCs did not correct the aggravated phenotype, suggesting that the reduced levels of the serglycin-dependent connective tissue type MC proteases MCPT5 and MCPT6 play only a minor role in the aggravated enteropathy found in infected SG−/− mice and that mucosal MCs play a more vital role. The gene discussed is SRGN; the disease is Abnormal intestine morphology.