The changed levels of IL-4 and IL-13 together with the altered pro-inflammatory cytokine profiles, the increased levels of IgE, impaired protease levels, and the aggravated enteropathy suggest that the balance between the Th1 and Th2 response profiles may be corrupted in the SG−/− mice, a notion that requires further investigation. The gene discussed is IGHE; the disease is Abnormal intestine morphology.