GH1 and acromegaly: Somatostatin analogs (SSAs) with long-acting release (octreotide and lanreotide) represent medical therapies of choice in acromegaly to control GH and IGF1 oversecretion because these agents specifically bind to the somatostatin receptor subtype 2, a membrane receptor highly expressed in somatotroph cells and whose activation leads to both antisecretory and antiproliferative effects (Chanson 2015).