ERBB2 and colorectal carcinoma: Significant gene association was observed only when the gene list was reduced to AR (mutated and causative of PAIS in the proband), MIR650 (already related to CRC pathogenesis and present in a rearranged chromosomal region), ERBB2 (determined to be functionally impaired by the candidate gene approach), and the 13 genes harboring truncating variants (identified by the whole-exome approach).