CRLF2 and malignant colon neoplasm: Specifically, the identified copy number gains in the chromosomal regions 1p36.22, involving the PRY domain-containing SOCS box protein 1 (SPSB1) gene; 14q32.33, involving the immunoglobulin heavy constant gamma 1 (IGHG1) gene; Xp221.33 or Yp11.32, encompassing the cytokine receptor-like factor 2 (CRLF2) gene; and the copy number loss of chromosomal region 10q21.3, involving the intronic region of the catenin α 3 (CTNNA3) gene, have been previously identified in human cancers other than colon cancer.