From the literature, four of these six genes (CHMP2B, DENND2D, KALRN, and TGM4) have been previously identified as being involved in oncogenesis, while 3 (MIR650, ADHFE1, and MEP1A) may be related to CRC development and differentiation (see all the references in Additional file 8: Table S8). The gene discussed is ADHFE1; the disease is colorectal carcinoma.