The proportions with diabetes and overweight/obesity, the lipid profiles (TG, LDL-C, TG/HDL-C, TC/HDL-C, LDL-C/HDL-C), fasting and postprandial plasma glucose, insulin, and C peptide were much higher in the HOMA-IR >2.69 group. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.