After a retrospective analysis of a series SS patients [32], we correlated the expression of some potential biomarkers with clinical parameters and found that nuclear expression of IGF-1R (Fig. 1d) and chemokine receptor CXCR4 together with age, tumour size and use of radiotherapy resulted to be strongly independent adverse prognostic factors for overall survival [33]. The gene discussed is IGF1R; the disease is neoplasm.