In terms of the aetiology of altered insulin/glucose dynamics, reductions in insulin sensitivity do not manifest in daughters of PCOS patients until after puberty, where although fasting insulin was not raised, 2 h-post glucose challenge insulin secretion is higher in girls whose mothers have PCOS19, indicative that altered insulin secretory response may also precede onset of IR in humans. This evidence concerns the gene INS and polycystic ovary syndrome.