For example, the levels of ERK signaling have a profound effect on adipocyte development 33, loss of ERK signaling inhibition leads to obesity in mice 34, and erk1‐/‐ mice resist obesity induced by high‐fat diet due to decreased adipogenesis and increased postprandial energy expenditure 33. This evidence concerns the gene MAPK3 and obesity due to melanocortin 4 receptor deficiency.