BDNF and Alzheimer disease: Furthermore, the novel object recognition test as well as the hippocampal BDNF ELISA indicated that ASO BDNF-NSC transplantation was insufficient to recover the declarative memory and BDNF level of AD mice (Fig. 7e,f), suggest that the engrafted BDNF-NSC-mediated cognitive improvement was blocked by BDNF knockdown.