BDNF and Alzheimer disease: Compared to a previous NSC-based study in AD reported by Blurton-Jones et al. 2, this study underlines the beneficial effects of BDNF in the fate of engrafted cells for developing as functionally matured neurons that contribute to the AD brain, and it provides further insight into the potential of engrafted cells in acting as functional neurons and integrating into synaptic circuits of the host (Supplementary Table S2).