Our results indicated that AD mice transplanted with BDNF-overexpressing NSCs (BDNF-NSCs) exhibited a better recovery in terms of their behavioral outcomes since the engrafted BDNF-NSCs were better able to survive, differentiate into neurons with a higher neurite complexity, and recovered more the synaptic density and BDNF level than control NSCs. The gene discussed is BDNF; the disease is Alzheimer disease.