In addition, the engrafted cells were surrounded by the post-synaptic terminals of endogenous neurons, and part of the PSD95 immunoreactivity was colocalized with the GFP immunoreactivity (Fig. 4b), implying that the engrafted cells were capable of forming synaptic connections with endogenous cells in the hippocampus of AD mice. Here, DLG4 is linked to Alzheimer disease.