VEGFA and neoplasm: In this case tumour growth was suppressed seven- to eightfold compared with the PBS group, and about twofold compared with the PolyMet carrier or the Metformin group, which suggests again that PolyMet successfully combine the intrinsic anticancer efficacy of Metformin with the tumour suppressive effects of VEGF siRNA to enhance the therapeutic activity of an anticancer gene therapy.