CASP3 and cancer: To complement these data, we investigated the effects of docetaxel on the expression of HIF-1α target genes (Glut1, CA9, LDHA, and BNIP3) involved in the metabolism of cancer cells and pro-apoptotic genes (CASP3, CASP8, and CASP10) in siJNK2-transfected MDA-MB-231 cells under hypoxic conditions.