CASP3 and metabolic dysfunction-associated steatohepatitis: Activation of apoptotic signaling relevant to human NASH and lipotoxicity [16,17] via increased expression in pro-apoptotic proteins BIM and p53 upregulated modulator of apoptosis (PUMA), and cleaved poly ADP ribose polymerase (PARP) and caspase 3 was observed at later time points (data for week 52 shown in Fig. 4A).