Interestingly, both collagen IV-osteopontin-FAK1 network (Supplementary Table 6), as well as an activin A-MMP-2-syntenin 2 network, both of which have been associated with HCC development in humans [25–29], were upregulated in B6/129 mice as compared to B6 after 52 weeks of WD SW diet. This evidence concerns the gene MMP2 and hepatocellular carcinoma.