Gene Set Enrichment Analysis, based on a priori defined sets of genes along specific pathways, demonstrated multiple pathways that were differentially activated with blood coagulation, TGF-β-Wnt, cytoskeletal remodeling and LRRK2 in Parkinsons disease as the top four pathways based on statistical significance (Fig. 4E and Supplementary Fig. 5). Here, LRRK2 is linked to Parkinson disease.