Whilst a number of reports in the literature have identified ARF6 and Rab35 individually as targets during bacterial infection (ARF6 is implicated in host cell invasion by both Shigella flexneri[38] and Salmonella enterica serovar Typhimurium [39] and Rab35 is known to be modulated by both uropathogenic E. coli (UPEC) [40] and the Legionella pneumophilia Dot/Icm effector AnkX [41]) concurrent modulation of the ARF6:Rab35 signaling axis by EHEC EspG represents a previously unappreciated strategy of host cell modulation by a bacterial pathogen. The gene discussed is RAB35; the disease is bacterial infectious disease.