Finally, the correlation of HK2- CIMP with clinical outcome suggests that HK2- CIMP HCCs could be regarded as a distinct subgroup of HCCs, and HK2-CGI hypermethylation, represented by −40 CpG hypermethylation, could be used as a biomarker for predicting prognosis of HCC patients. This evidence concerns the gene HK2 and hepatocellular carcinoma.