Neha et al. reported that inhibiting ADAM10 expression subsequently diminishes β-catenin intracellular signaling and repress TCF/LEF target gene expression [27], which is similar to our founding that miR-655-3p could reduce E-cadherin protein level and inhibit β-catenin pathway by target regulating ADAM10 in HCC. This evidence concerns the gene HNF4A and hepatocellular carcinoma.