As Il27ra−/− mice displayed improved clearance of C. parapsilosis, we wanted to determine whether IL-27 affects the host inflammatory response to C. parapsilosis. Of note, Il27ra−/− mice demonstrated increased serum levels of some proinflammatory cytokines (IL-12p40, IL-6) 1 wk post infection with C. parapsilosis (Fig. 7A). The gene discussed is IL27; the disease is infection.