Furthermore, immunohistochemical analysis for XIAP and in situ hybridization for miR-410, in sections from additional biopsies, revealed increased staining of XIAP, in the nuclei of epithelial cells, and decreased staining of miR-410 in the cholangiocarcinoma tumors samples (Fig. 4c), indicating the human relevance of this pathway in cholangiocarcinoma oncogenesis. The gene discussed is XIAP; the disease is cholangiocarcinoma.