The relative expressions of Notch1 mRNA in the following groups of blank group, negative control group and shRNA-Notch1 group after 72h lentivirus infection were 1.002 ± 0.042, 0.909 ± 0.041 and 0.251 ± 0.049 respectively. The gene discussed is NOTCH1; the disease is lentivirus infection.