Only E2F5, a probable oncogene in HCC, was consistently downregulated in the FOXN3-overexpressing HCC cell lines and significantly negatively correlated with FOXN3 in the 372 HCC tissues (P = 0.0002, R = −0.189, Figure 4C and Supplementary Figure S2B). Here, FOXN3 is linked to hepatocellular carcinoma.