Interestingly, although c-MYC expression is downregulated in the Asian derived-cell line KATO III and to a lesser extent in SNU-16, a cell line with high c-MYC amplification, there was a complete lack of antiproliferative activity of (+)-JQ1 and PNZ5, indicating that the antiproliferative effect is independent of c-MYC levels, a finding that has also been reported for leukemia cell lines [57]. Here, MYC is linked to leukemia.