E-cadherin gene (CHD1), another important target of EZH2, is involved in epithelial-mesenchymal transition (EMT), invasion and migration [14], while Bim, TRAIL and FBO32, three molecules involved in apoptosis [15, 16], and Vasohibin1, a molecule closely associated with tumor angiogenesis [17], are also suppressed by EZH2. This evidence concerns the gene EZH2 and neoplasm.