EIF2S1 and neoplasm: In transformed rodent fibroblasts we have previously shown that the expression of Beclin1 and LC3 can be regulated in a PERK dependent manner, in general agreement with the present data in human tumor cells showing that dominant negative eIF2 alpha also suppressed [sorafenib/regorafenib + sildenafil] –induced expression of the autophagy regulatory, and autophagy facilitating proteins, Beclin1 and LC3.