TP53 and non-small cell lung carcinoma: In ADOR tumor cells, a July 2015 PDX model of non-small cell lung cancer that was fully localized within one lobe of the right lung, we discovered using genetic screening tools that these cells did not contain any “well described” mutated drivers for tumor growth, including “the guardian of the genome,” p53 (Figure 3A; 50 genes were tested, only 5 showed any genetic variation from the expected sequence).