Moreover, high HMGA2 expression levels correlate with shorter survival time in glioma patients using the CGGA (The Chinese Glioma Genome Atlas) dataset [34] (Supplementary Figure S1E), which is consistent with reports showing higher levels of IL-6/HMGA2/SOX2 expression indicated shorter overall survival period in GBM patients [35]. Here, HMGA2 is linked to central nervous system cancer.