Using qRT-PCR, we confirmed that the expression levels of FOXM1, PLAU, CYR61, THBS1 and ADAM9 are indeed significantly down-regulated upon HMGA2 depletion in TPC1115 GICs, U87MG glioma cells and SK-N-SH neuroblastoma cells (Supplementary Figure S5B-S5D). The gene discussed is CCN1; the disease is central nervous system cancer.