IGFBP3 and neoplasm: Many tumor metastasis genes, such as tryptophan 2,3-dioxygenase (TDO2), integrin subunit beta 2 (ITGB2), laminin, beta 3 (LAMB3), SNAI2, zinc finger E-box binding homeobox 1 (ZEB1), insulin-like growth factor–binding protein 7 (IGFBP7), insulin-like growth factor–binding protein 3 (IGFBP3), and Meis homeobox 1 (MEIS1), were identified in the overlap of these three groups, and the mRNA expression levels of LAMB3, SNAI2, and IGFBP7 were verified by RT-qPCR assays (Figure 6C).