CAV1 and neoplasm: Our group has previously shown that a) CAV1 function as a tumor suppressor is conditioned by the expression of E-cadherin and that presence of the latter blocks CAV1-enhanced lung metastasis [28, 29, 37]; b) the expression of CAV1 in metastatic cells lacking E-cadherin enhances cell polarization, directional migration and cell persistency [42], and c) CAV1 enhanced migration of B16F10 cells in Transwell assays is not observed upon expression of the Y14F mutant protein [42].