There were higher TOP2A expression levels in AC compared to TC (Mann-Whitney-Test: U = −3.359, p = 0.001) and in SCLC/LCNEC compared to AC (U = −4.537, p < 0.001/U = −3.266, p < 0.001) (see Figure 3). This evidence concerns the gene TOP2A and large cell neuroendocrine carcinoma.