When evaluating the Ki-67-Hotspots the analysed cut-off value between TC and AC amounted to 1.5% (AUC = 0.930, p < 0.001, sensitivity = 0.952, 1-specificity = 0.167), between AC and SCLC to 22.0% (AUC = 0.974, p < 0.001, sensitivity = 0.900, 1-specificity = 0.095) and between AC and LCNEC to 35.00% (AUC = 1.000, p < 0.001, sensitivity = 1.000, 1-specificity = 0.000). Here, MKI67 is linked to large cell neuroendocrine carcinoma.