Hence, the aims of our study were (1) to compare the transcriptome of normal Fallopian tube secretory epithelial cells with that of ovarian cancer cells in order to uncover genes and pathways modified during the transformation process; (2) to investigate PAX8 downstream gene regulatory network in physiological and pathological conditions to identify genes and pathways regulated by PAX8 that could be additional targets for the therapy of ovarian carcinoma. Here, PAX8 is linked to ovarian carcinoma.