Matrix metalloproteinase 14 (MMP-14), a membrane-anchored MMP, is not only able to degrade structural extracellular matrix (ECM) components such as fibronectin, vitronectin, laminin-1, laminin-5, fibrin, and collagen, but also capable of activating MMP-2, thereby promoting tumor invasion and metastasis [3]. The gene discussed is MMP14; the disease is neoplasm.