According to the expression level of JARID2 in HCC cell lines and biological characteristics of HCC cell lines, [25, 26] we overexpressed JARID2 in HepG2 cells (Supplementary Figure 2C) and stably knocked down JARID2 in HCCLM3 (Supplementary Figure 2D), MHCC97-H cells (Supplementary Figure 2E). The gene discussed is JARID2; the disease is hepatocellular carcinoma.