HCC patients with high JARID2 expression had lower DFS (1-, 3- and 5-year DFS: 73.7%, 39.5%, 11.2% vs.85.7%, 67.9%, 50.0%, P = 0.002; Figure 2D1), lower OS (1-, 3- and 5-year OS: 78.9%, 55.3%, 24.9% vs. 89.3%, 75.0%, 57.1%, P = 0.001; Figure 2D2) and a significantly higher early recurrence rate (recurrence within 2 years: 50% vs. 17.9%, P = 0.010; Figure 2D3) than who with low JARID2 expression. Here, JARID2 is linked to hepatocellular carcinoma.