JARID2 and hepatocellular carcinoma: Interestingly, among three different subtypes of HCC including small hepatocellular carcinoma (SHCC, the diameter of HCC ≤ 5 cm), solitary large hepatocellular carcinoma (SLHCC, only one nodule, and diameter > 5 cm, and grows expansively within an intact capsule or pseudocapsule), nodular hepatocellular carcinoma (NHCC, has more than 2 nodules), [2, 24] JARID2 expression level in NHCC with the greatest metastatic potential and poorest clinical outcome was significant higher than that in SLHCC and SHCC with relatively better clinical outcome [2, 24] (Figure 1D1).