The unanticipated ability of one germline BRCA1 hit to reprogram breast epithelial host metabolism towards increased anabolism should broaden our understanding of “gatekeeper” or “caretaker” tumor-suppressor genes as well as improving our knowledge of the ultimate molecular requirements for BRCA1-driven neoplastic transformation in a tissue- and cell-type-specific manner. Here, BRCA1 is linked to neoplasm.