In summary, our data showed that a novel natural product, Ary can effectively treat cervical cancer in vivo and in vitro, its mechanism is that it induces cervical cancer cell apoptosis through mitochondrial membrane potential, and arrests cells at G1/S-phase through constantly activating ERK1/2 to locate the nucleolus and upregulating cyclin A2 and Cdk2 expression (Figure 8). Here, MAPK3 is linked to cervical cancer.