LYPLA1 and cancer: In the current study, we observed a significant cytotoxic effect of DSF or DSF+Cu against in-culture activated ha-PSCs and HapT1 cancer cells (Figure 5A and 5B); however, the failure of DSF to perform in a physiologically relevant HapT1 orthotopic tumor animal model (Figure 6) strongly suggests the importance of using appropriate animal models in preclinical drug validation.