Since convincing evidence has highlighted that Ago proteins, HDL, and exosomes transport and deliver miRNAs to recipient cells having different regulatory requirements, we also investigated the specific carriers of circulating MM miRNAs, hypothesizing that vesicle-, Ago2-, and HDL-associated miRNAs may originate from cells reflecting cell type-specific expression and release mechanisms. The gene discussed is AGO2; the disease is Miyoshi myopathy.