To our knowledge, a parallel analysis of miRNAs and HMGB1 has never been performed, but combined analysis of mesothelin and either miR-126-3p or miR-103a-3p has improved the specificity and sensitivity of each marker alone in distinguishing asbestos-exposed from MM patients (Figure 7A-7B-7C) [85, 89]. This evidence concerns the gene MSLN and Miyoshi myopathy.